Blog Post

New PET-CT using FET

26/04/2022

FET PET-CT is a scan that can detect brain tumours – both primary and metastatic. FET PET-CT is indicated in the use of imaging of brain metastases as follows

  • Detection of viable tumour tissue; Radiolabelled amino acid imaging is superior to FDG PET, CT and MRI for differentiation of viable tumour tissue from treatment induced non-malignant changes such as post-operative change, oedema or radiation necrosis. FET PET is also superior to FDG PET for low grade recurrence.
  • Tumour Delineation; superior for estimation of true tumour extension in both low and high-grade gliomas.
  • Selection of biopsy site; FET is recommended to guide stereotactic biopsy for classification and grading of glioma.
  • Non-Invasive tumour grading; FET PET may aid in differentiating high grade gliomas from histologically benign brain tumours or non-neoplastic lesions. Oligodendroglioma and oligo-astrocytoma could have greater uptake than high grade gliomas.
  • Therapy Planning; FET PET used in conjunction with anatomical imaging may better define tumour volumes for resection of radiation therapy.
  • Tumour response; FET PET may predict the response to chemo and radiation therapy as it allows for earlier detection of residual tumour post-surgery.

Radiolabelled amino acids offer improvement over anatomical imaging (CT/MRI) as well as FDG PET-CT due to the low uptake of amino acids in normal brain tissue and therefore may be more tumour specific as uptake is less impacted by inflammation (1,2)

FET PET-CT imaging is offered at all Qscan clinics with PET-CT services. Click here to find a clinic near you. 

References

1.        EANM Procedure Guidelines for Brain Tumour Imaging using Radiolabelled Amino Acid Analogues, Vander Borght et al 2006

2.        Impact of F18-Fluoro-ethyl-tyrosine PET Imaging on target definition for radiation therapy of high-grade glioma, Rosenschold et al, Neuro-Oncology, Vol 17, Issue 5, May 2015.